Journal
MOLECULAR HUMAN REPRODUCTION
Volume 16, Issue 12, Pages 960-968Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gaq064
Keywords
intrauterine growth restriction (IUGR); decidua basalis; pre-eclampsia; HUNT2; STOX genes
Funding
- Research Council of Norway
- Fulbright foundation for educational exchange
- Central Norway Regional Health Authority
- Norwegian University of Science and Technology
- National Institutes of Health [HD049847, MH059490]
- Southwest Foundation Forum
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Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR.
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