Journal
MOLECULAR HUMAN REPRODUCTION
Volume 15, Issue 3, Pages 139-147Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gap007
Keywords
oocyte; homologs; meiosis; recombination; aneuploidy
Funding
- National Health and Medical Research Council (NHMRC)
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Homologous chromosomes are segregated during the first meiotic division (meiosis I). Unfortunately, human oocytes are particularly susceptible to mis-segregation errors, so generating aneuploid, often non-viable, embryos. Here we review the cell biology of meiosis I and how homolog disjunction is regulated for mammalian oocytes. We focus on the activity of the anaphase-promoting complex/cyclosome (APC/C), which is responsible for timely degradation of the cohesin component, REC8 and the cyclin B regulatory subunit of maturation-promoting factor, both essential steps for meiosis I completion. In particular, we examine the role played by the spindle assembly checkpoint in controlling the APC/C activity, and in so doing ensuring accurate disjunction of homologs.
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