Journal
MOLECULAR GENETICS AND METABOLISM
Volume 112, Issue 1, Pages 40-43Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymgme.2014.02.015
Keywords
Late-onset Pompe disease; Muscle strength; Muscle volume; Enzyme replacement therapy; Walking capacity; Respiratory function
Funding
- BEVICA Foundation
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Pompe disease is a rare, inherited metabolic myopathy characterized by progressive weakness of the proximal limb and respiratory muscles. We report the findings from four patients with late-onset Pompe disease treated with alpha-glucosidase (Myozyme) for 2 (n = 2) and 6 (n = 2) years, and monitored with isokinetic dynamometry, 6-minute walking test (6MWT), and vital capacity. Patients were evaluated after 6, 12, 24, 36, 48, 60, and 72 months. In two patients, muscle size estimated by MRI and DXA scanning was also performed prior to and following 6 months of treatment. After 2 years of alpha-glucosidase treatment, maximal isokinetic muscle strength increased by 11% (0%-50%) [median (range)] and 6MWT improved by 18% (2%-40%). In the two patients treated for 6 years, the increase in muscle strength stabilized at 40% and 6MWT stabilized at 32%. The improvements primarily occurred during the first 6 months of treatment. Interestingly, the weakest muscle groups seemed to benefit more than those less affected, and greater improvements occurred for flexor muscles compared to extensor muscles. Vital capacity did not improve on treatment (C) 2014 Elsevier Inc. All rights reserved.
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