Journal
MOLECULAR GENETICS AND METABOLISM
Volume 99, Issue 3, Pages 256-262Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymgme.2009.10.012
Keywords
L-Serine; D-Serine; 3-PGDH deficiency; PSAT deficiency; PSPH deficiency
Funding
- Wilhelmina Children's Foundation [WK05.03]
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The de nova synthesis of the amino acid L-serine plays an essential role in the development and functioning of the central nervous system (CNS). L-Serine displays many metabolic functions during different developmental stages; among its functions providing precursors for amino acids, protein synthesis, nucleotide synthesis, neurotransmitter synthesis and L-serine derived lipids. Patients with congenital defects in the L-serine synthesizing enzymes present with severe neurological abnormalities and underscore the importance of this synthetic pathway. In this review, we will discuss the cellular functions of the L-serine pathway, structure and enzymatic properties of the enzymes involved and genetic defects associated with this pathway. (C) 2009 Elsevier Inc. All rights reserved.
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