Journal
MOLECULAR GENETICS AND METABOLISM
Volume 96, Issue 3, Pages 145-147Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymgme.2008.11.161
Keywords
CYP4F2; Single-nucleotide polymorphism; Haplotype; Case-control study; Gender-specific
Funding
- Toray Co., Ltd.
- Ministry of Education, Culture, Sports, Science and Technology of Japan (High-Tech Research Center, Nihon University)
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This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P=0.006, P=0.001 and P=0.002, respectively). (C) 2008 Elsevier Inc. All rights reserved.
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