Journal
MOLECULAR ENDOCRINOLOGY
Volume 24, Issue 1, Pages 11-21Publisher
OXFORD UNIV PRESS INC
DOI: 10.1210/me.2009-0212
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Funding
- National Institutes of Health [ES012479, ES014626, DK076962]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK076962] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES014626, R01ES012479] Funding Source: NIH RePORTER
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Steroid hormones are essential in normal physiology whereas disruptions in hormonal homeostasis represent an important etiological factor for many human diseases. Steroid hormones exert most of their functions through the binding and activation of nuclear hormone receptors (NRs or NHRs), a superfamily of DNA-binding and often ligand-dependent transcription factors. In recent years, accumulating evidence has suggested that NRs can also regulate the biosynthesis and metabolism of steroid hormones. This review will focus on the recent progress in our understanding of the regulatory role of NRs in hormonal homeostasis and the implications of this regulation in physiology and diseases. (Molecular Endocrinology 24: 11-21, 2010)
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