Journal
MOLECULAR ECOLOGY RESOURCES
Volume 10, Issue 6, Pages 915-934Publisher
WILEY
DOI: 10.1111/j.1755-0998.2010.02891.x
Keywords
ascertainment bias; DEco-TILLING; linkage disequilibrium; next-generation sequencing; population genetics; SNP
Funding
- University of Alaska
- University of Alaska Fairbanks Pollock Cooperative Conservation Research Center
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Single nucleotide polymorphisms (SNPs) have gained wide use in humans and model species and are becoming the marker of choice for applications in other species. Technology that was developed for work in model species may provide useful tools for SNP discovery and genotyping in non-model organisms. However, SNP discovery can be expensive, labour intensive, and introduce ascertainment bias. In addition, the most efficient approaches to SNP discovery will depend on the research questions that the markers are to resolve as well as the focal species. We discuss advantages and disadvantages of several past and recent technologies for SNP discovery and genotyping and summarize a variety of SNP discovery and genotyping studies in ecology and evolution.
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