Journal
MOLECULAR DIVERSITY
Volume 23, Issue 1, Pages 215-259Publisher
SPRINGER
DOI: 10.1007/s11030-018-9870-z
Keywords
Chan-Lam coupling; Cross-coupling reactions; Boronic acids; N-heterocycles; N-Arylation
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Chan-Lam coupling is one of the most popular and easy methods to perform arylation of amines (N-arylations). This cross-coupling is generally performed by reacting aryl boronate derivatives with a variety of substrates involving nitrogen containing functional groups such as amines, amides, ureas, hydrazine, carbamates. This article summarizes the synthetic applications of this reaction and the efforts of scientists to develop novel and efficient methodologies for this reaction.
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