Journal
MOLECULAR DIVERSITY
Volume 18, Issue 3, Pages 535-543Publisher
SPRINGER
DOI: 10.1007/s11030-014-9522-x
Keywords
2-Pyridone-3-carboxylic acid; Functionalized 2-pyridones; 3-Formyl chromone; Multicomponent reactions (MCRs); Domino reaction; Diammonium hydrogen phosphate; Meldrum's acid
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Funding
- Alexander von Humboldt foundation
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Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum's acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally friendly profile are the advantages of this method for the synthesis of 2-pyridone-3-carboxylic acid derivatives.
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