Journal
MOLECULAR DIVERSITY
Volume 17, Issue 2, Pages 389-407Publisher
SPRINGER
DOI: 10.1007/s11030-013-9439-9
Keywords
Biginelli; 3, 4-Dihydropyrimidin-2(1H)-ones; Asymmetric synthesis; Multicomponent reactions (MCRs)
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Funding
- Research Council of Alzahra University
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The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1)-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction.
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