Journal
MOLECULAR DIVERSITY
Volume 15, Issue 2, Pages 497-505Publisher
SPRINGER
DOI: 10.1007/s11030-010-9272-3
Keywords
Pyrazolo[4,3-f]quinoline derivatives; Diversity-oriented synthesis; Multi-component reactions; Microwave irradiation; MW; DOS; MCR
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Funding
- National Science Foundation of China [21072163, 21002083]
- Science Foundation in Interdisciplinary Major Research Project of Xuzhou Normal University [09XKXK01]
- Science & Technology Foundation of Xuzhou municipal government [XM08C027]
- Natural Science Foundation [09KJB150011]
- Jiangsu high education committee [08QLT001]
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Six new series of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities were synthesized by the three-component reactions of aromatic aldehydes, 5-aminoindazole, and various cyclic 1,3-dicarbonyl compounds under microwave irradiation. This protocol has the valuable features of structural diversity of products, broader substrate scope, operational simplicity, high yields, and short reaction time. Moreover, the structure of compound 88a was confirmed by an X-ray crystallographic analysis and attested to the chemoselectivity of reaction where 1-methyl barbituric acid participated.
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