Journal
MOLECULAR DIVERSITY
Volume 14, Issue 4, Pages 635-641Publisher
SPRINGER
DOI: 10.1007/s11030-009-9197-x
Keywords
2,4,5-Trisubstituted imidazoles; 1,2,4,5-Tetrasubstituted imidazoles; Wells-Dawson; Benzil; Benzoin
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Funding
- Research Council of Arak University
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Heteropolyacid H6P2W18O62 center dot 24H(2)O (WD) supported on silica (WD/SiO2) has been used as an effective catalytic system for the synthesis of various 1,2,4,5-tetrasubstituted imidazoles by four-component condensation of benzil, aldehydes, amines and ammonium acetate under solvent-free conditions. This approach can be useful for three-component synthesis of 2,4,5-trisubstituted imidazoles. The same reactions were repeated by using benzoin instead of benzil.
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