Journal
MOLECULAR DIVERSITY
Volume 12, Issue 2, Pages 85-91Publisher
SPRINGER
DOI: 10.1007/s11030-008-9079-7
Keywords
aqueous media; diammonium hydrogen phosphate (DAHP); pyrano[2,3-d]pyrimidinone; domino Knoevenagel-Michael addition; multicomponent reaction (MCR)
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Funding
- National Research Institute for Science Policy (NRISP) [3234]
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Diammonium hydrogen phosphate, (NH(4))(2)HPO(4), was used as a catalyst for one-pot, three-component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric/thiobarbituric acid in aqueous ethanol at room temperature. This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst.
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