Journal
MOLECULAR DIVERSITY
Volume 12, Issue 3-4, Pages 191-196Publisher
SPRINGER
DOI: 10.1007/s11030-008-9089-5
Keywords
Diarylpyrimidinones; Solvent-free reactions; Solid acid catalysts; Sulfamic acid; Multi-component reactions
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A rapid and efficient one-pot method for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones and related heterocycles is described. The condensation of acetophenone derivatives, aldehydes and urea in the presence of sulfamic acid was employed to synthesize a variety of pyrimidinones in moderate to excellent yields. The scope and limitations of this method are described.
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