4.5 Article

A novel method for the synthesis of substituted 3,4-dihydrocoumarin derivatives via isocyanide-based three-component reaction

Journal

MOLECULAR DIVERSITY
Volume 12, Issue 3-4, Pages 197-202

Publisher

SPRINGER
DOI: 10.1007/s11030-008-9090-z

Keywords

Isocyanide; 3,4-Dihydrocoumarin derivatives; Multi-component reactions; 2-Hydroxybenzaldehydes

Funding

  1. Research Council of Shahid Beheshti University

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A new one-pot procedure for the efficient synthesis of novel 3,4-dihydrocoumarin derivatives using commercially available substituted 2-hydroxybenzaldehydes, Meldrum's acid, and isocyanides by a three-component condensation reaction in dichloromethane at room temperature without using any catalysts and activation was developed.

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