Journal
MOLECULAR DIVERSITY
Volume 13, Issue 1, Pages 57-61Publisher
SPRINGER
DOI: 10.1007/s11030-008-9098-4
Keywords
4H-thiopyran; Pyrimidine nucleoside derivatives; Multi-component reaction; Ionic liquid; Thioamide
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Funding
- National Natural Science Foundation of China [20772025]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [2008HASTIT006]
- Department of Education of Henan Province [2008A150013]
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One-pot multi-component reactions of aldehydes, cyanothioacetamide and malononitrile promoted by ionic liquid proved to be an efficient way for the synthesis of thiopyran derivatives. Without any added catalyst, both aromatic and aliphatic aldehydes participated in this reaction smoothly. As an application of this method, a pyrimidine nucleoside-thiopyran chimera with potential biological activities was obtained in high yield from 5-formyl-2'-deoxyuridine. In addition, the ionic liquid used can be easily recovered and effectively reused for at least 5 times.
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