Journal
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
Volume 555, Issue -, Pages 271-279Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/15421406.2012.635556
Keywords
Collagen; fibroblast cells; niflumic acid; scaffolds; wound dressing
Funding
- EU
- [POSDRU/89/1.5/S/52432]
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The aim of this study was to develop modern wound dressings such as controlled drug delivery systems. These systems consist in collagen as release support and niflumic acid as drug. The scaffolds were prepared by lyophilization in order to obtain porous structures and were evaluated by release profile of niflumic acid, water absorption, collagenase degradation and biocompatibility with fibroblast cells. The collagen scaffold with 0.75% niflumic acid solved in laurel oil was optimal in terms of biodegradability, absorbability and fibroblast cells biocompatibility. Thus, the obtained collagen scaffolds could be used as wound dressings with absorbent, antibacterial and anti-inflammatory properties.
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