Journal
MOLECULAR CELL
Volume 56, Issue 1, Pages 18-27Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2014.09.012
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Funding
- NIH [DP1CA174418, R01HD42012]
- G. Harold & Leila Mathers Foundation
- Ellison Medical Foundation Senior Scholar Award
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Piwi proteins and Piwi-interacting RNAs (piRNAs) are essential for gametogenesis, embryogenesis, and stem cell maintenance in animals. Piwi proteins act on transposon RNAs by cleaving the RNAs and by interacting with factors involved in RNA regulation. Additionally, piRNAs generated from transposons and psuedogenes can be used by Piwi proteins to regulate mRNAs at the posttranscriptional level. Here we discuss piRNA biogenesis, recent findings on posttranscriptional regulation of mRNAs by the piRNA pathway, and the potential importance of this posttranscriptional regulation for a variety of biological processes such as gametogenesis, developmental transitions, and sex determination.
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