Journal
MOLECULAR CELL
Volume 56, Issue 1, Pages 128-139Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2014.08.004
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Funding
- NIH [R01 GM078455, R01 DK49780, R01 CA166274, 1F32DK09883901, 5T32HL007954-13F32]
- American-Italian Cancer Foundation Post-Doctoral Research Fellowship
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In unicellular organisms, initiation is the rate-limiting step in transcription; in metazoan organisms, the transition from initiation to productive elongation is also important. Here, we show that the RNA polymerase II (RNAPII)-associated multiprotein complex, Integrator, plays a critical role in both initiation and the release of paused RNAPII at immediate early genes (IEGs) following transcriptional activation by epidermal growth factor (EGF) in human cells. Integrator is recruited to the IEGs in a signal-dependent manner and is required to engage and recruit the super elongation complex (SEC) to EGF-responsive genes to allow release of paused RNAPII and productive transcription elongation.
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