Journal
MOLECULAR CELL
Volume 49, Issue 3, Pages 411-421Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2013.01.020
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- EMBO Long-Term Fellowships
- NIH [GM56433, AI91575]
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Cells face a constant challenge as they produce new proteins. The newly synthesized polypeptides must be folded properly to avoid aggregation. If proteins do misfold, they must be cleared to maintain a functional and healthy proteome. Recent work is revealing the complex mechanisms that work cotranslationally to ensure protein quality control during biogenesis at the ribosome. Indeed, the ribosome is emerging as a central hub in coordinating these processes, particularly in sensing the nature of the nascent protein chain, recruiting protein folding and translocation components, and integrating mRNA and nascent chain quality control. The tiered and complementary nature of these decision-making processes confers robustness and fidelity to protein homeostasis during protein synthesis.
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