Journal
MOLECULAR CELL
Volume 52, Issue 4, Pages 473-484Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2013.10.032
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Funding
- Danish National Research Foundation [DNRF58]
- Novo Nordisk Foundation
- Danish Cancer Society
- Agence Nationale pour la Recherche [ANR-08-Blan-0038-01, ANR-12-BSV8-0014-01]
- CNRS
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0038, ANR-12-BSV8-0014] Funding Source: Agence Nationale de la Recherche (ANR)
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Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly found RNAs have functions and how many are byproducts of functional, or spurious, transcription events. Cells control the accumulation of many opportunistic transcripts by limiting their synthesis and by provoking their early transcription termination and decay. In this review, we use S. cerevisiae and mammalian cells as models to discuss the circumstances by which pervasive transcripts are produced and turned over. This ultimately relates to the likelihood, and potential mechanism, of molecular function.
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