Journal
MOLECULAR CELL
Volume 49, Issue 4, Pages 759-771Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2013.01.040
Keywords
-
Categories
Funding
- Netherlands Genomics Initiative
- NWO-ALW VICI
- ERC [293662]
- European Research Council (ERC) [293662] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Chromatin governs gene regulation and genome maintenance, yet a substantial fraction of the chromatin proteome is still unexplored. Moreover, a global model of the chromatin protein network is lacking. By screening >100 candidates we identify 42 Drosophila proteins that were not previously associated with chromatin, which all display specific genomic binding patterns. Bayesian network modeling of the binding profiles of these and 70 known chromatin components yields a detailed blueprint of the in vivo chromatin protein network. We demonstrate functional compartmentalization of this network, and predict functions for most of the previously unknown chromatin proteins, including roles in DNA replication and repair, and gene activation and repression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available