Journal
MOLECULAR CELL
Volume 39, Issue 1, Pages 133-144Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2010.06.010
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [90813035, 30890044, 30570731]
- National Basic Research Program of China [2006CB503908, 2006CB503909, 2004CB518603, 2003CB715905]
- 111 Project
- Natural Science Foundation of Jiangsu Province [BK2004082, BK2006714]
Ask authors/readers for more resources
MicroRNAs (miRNAs) are a class of noncoding RNAs that regulate target gene expression at the posttran-scriptional level. Here, we report that secreted miRNAs can serve as signaling molecules mediating intercellular communication. In human blood cells and cultured THP-1 cells, miR-150 was selectively packaged into microvesicles (MVs) and actively secreted. THP-1-derived MVs can enter and deliver miR-150 into human HMEC-1 cells, and elevated exogenous miR-150 effectively reduced c-Myb expression and enhanced cell migration in HMEC-1 cells. In vivo studies confirmed that intravenous injection of THP-1 MVs significantly increased the level of miR-150 in mouse blood vessels. MVs isolated from the plasma of patients with atherosclerosis contained higher levels of miR-150, and they more effectively promoted HMEC-1 cell migration than MVs from healthy donors. These results demonstrate that cells can secrete miRNAs and deliver them into recipient cells where the exogenous miRNAs can regulate target gene expression and recipient cell function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available