Journal
MOLECULAR CELL
Volume 40, Issue 3, Pages 465-480Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2010.10.021
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Funding
- National Institutes of Health (NIH) [DK071962, GM037346, DK070149, GM75061]
- Israel Science Foundation
- USA-Israel Binat onal Science Foundation
- Israel Cancer Association
- FWF [S-9304-B05]
- American Heart Association [09POST2110034]
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We show that Ydr049 (renamed VCP/Cdc48-associated mitochondrial stress-responsive-Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the cytosol to mitochondria upon mitochondrial stress. Cells lacking Vms1 show progressive mitochondrial failure, hypersensitivity to oxidative stress, and decreased chronological life span. Both yeast and mammalian Vms1 stably interact with Cdc48NCP/p97, a component of the ubiquitin/proteasome system with a well-defined role in endoplasmic reticulum-associated protein degradation (ERAD), wherein misfolded ER proteins are degraded in the cytosol. We show that oxidative stress triggers mitochondrial localization of Cdc48 and this is dependent on Vms1. When this system is impaired by mutation of Vms1, ubiquitin-dependent mitochondrial protein degradation, mitochondrial respiratory function, and cell viability are compromised. We demonstrate that Vms1 is a required component of an evolutionarily conserved system for mitochondrial protein degradation, which is necessary to maintain mitochondrial, cellular, and organismal viability.
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