Journal
MOLECULAR CELL
Volume 40, Issue 2, Pages 205-215Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2010.09.027
Keywords
-
Categories
Funding
- National Institutes of Health (NIH) [RO1-CA133404]
- National Cancer Institute (NCI) [PO1-CA42063, P30-CA14051]
Ask authors/readers for more resources
MicroRNAs (miRNAs) are a class of 22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression patterns. This decision is partly mediated by miRNA functions, in particular by modulating the amount of miRNAs, the amount of mRNA targets, or the activity/mode of action of miRNA-protein complexes. In turn, these changes determine the specificity, timing, and concentration of gene products expressed upon stresses. Dysregulation of these processes contributes to chronic diseases, including cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available