Journal
MOLECULAR CELL
Volume 37, Issue 3, Pages 299-310Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2010.01.025
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Funding
- NCI NIH HHS [F32 CA101444] Funding Source: Medline
- NIAID NIH HHS [R01 AI040646, R01 AI040646-16] Funding Source: Medline
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B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.
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