DNA Repair Has a New FAN1 Club

In recent issues of Molecular Cell, Cell, and Science, Smogorzewska et al. (2010), MacKay et al. (2010), Kratz et al. (2010), and Liu et al. (2010) identify FAN1 as a nuclease that is recruited to sites of interstrand crosslinks by ubiquitylated FANCD2, where it participates in DNA repair. The identification of FAN1 fills a missing link in interstrand crosslink DNA repair.