Journal
MOLECULAR CELL
Volume 30, Issue 6, Pages 657-666Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2008.04.013
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Funding
- NIGMS NIH HHS [R01 GM049044, GM49044, R01 GM057829-09, GM57829, R01 GM049044-16, R01 GM057829] Funding Source: Medline
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The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.
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