Journal
MOLECULAR CELL
Volume 29, Issue 1, Pages 1-7Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2007.12.010
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Funding
- NIGMS NIH HHS [GM79477] Funding Source: Medline
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The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles' remain largely unresolved.
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