Journal
MOLECULAR CARCINOGENESIS
Volume 54, Issue 9, Pages 742-750Publisher
WILEY
DOI: 10.1002/mc.22137
Keywords
ncRAN; colorectal cancer; RNA interference; prognosis
Categories
Funding
- National Clinical Key Discipline
- Clinical Key Discipline Fund by Ministry of Health
- Academic Award for Doctoral Candidates by Ministry of Education
- Priority of Shanghai key discipline of medicine
- Shanghai R&D public service platform construction projects [12DZ2295100]
- National Natural Science Foundation of China [81071791]
- Mingdao Fund for Medical Graduate Student by Shanghai Medical College
- Shanghai Science and Technology Development Fund [10DJ1400500]
Ask authors/readers for more resources
Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) play critical roles in regulating cellular processes, such as cell growth and apoptosis, as well as cancer progression and metastasis. ncRAN (non-coding RNA expressed in aggressive neuroblastoma) was previously shown to be dramatically up-regulated and associated with poor prognosis in human neuroblastoma. This lncRNA also plays an important role in bladder cancer growth and invasion. Colorectal cancer (CRC) progression typically follows a complex cascade from primary malignancy to distant metastasis, but whether the aberrant expression of ncRAN in CRC is associated with malignancy, metastasis or prognosis remains unknown. In this study, we demonstrated that ncRAN expression is significantly down-regulated in tumor tissue and CRC cell lines compared with adjacent normal tissue and a normal intestinal mucous cell line. Reduced expression of ncRAN was detected in poorly differentiated or undifferentiated tumors and in tumors with liver metastases. Kaplan-Meier analysis indicated that patients with lower ncRAN expression have a worse overall survival. Moreover, multivariate analysis revealed that decreased expression of ncRAN is an independent predictor of overall survival. Our experimental data indicated that ncRAN mediates the in vitro migration and invasion of CRC cells. Together, these results suggest that ncRAN might represent a novel prognostic indicator, a biomarker for the early detection of metastasis and a target for gene therapy in CRC. (c) 2014 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available