Journal
MOLECULAR CARCINOGENESIS
Volume 48, Issue 4, Pages 389-399Publisher
WILEY
DOI: 10.1002/mc.20501
Keywords
DNA repair; gene targeting; gene modification; interstrand cross-link repair
Categories
Funding
- NIH [R01CA64186, R01HL082655]
- MSTP Training [5T32GM07205]
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Triplex-forming oligonucleotides (TFOs) are gene targeting tools that can bind in the major groove of duplex DNA in a sequence-specific manner. When bound to DNA, TFOs can inhibit gene expression, can position DNA-reactive agents to specific locations in the genome, or can induce targeted mutagenesis and recombination. There is evidence that third strand binding, alone or with an associated cross-link, is recognized and metabolized by DNA repair factors, particularly the nucleotide excision repair pathway. This review examines the evidence for DNA repair of triplex-associated lesions. (C) 2008 Wiley-Liss, Inc.
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