Journal
MOLECULAR CARCINOGENESIS
Volume 48, Issue 4, Pages 309-318Publisher
WILEY
DOI: 10.1002/mc.20512
Keywords
alternative DNA structures; DNA repeats; DNA damage checkpoints; replication; chromosomal fragility
Categories
Funding
- NIH [GM60987, GM063066]
Ask authors/readers for more resources
DNA sequences that are prone to adopting non-B DNA secondary structures are associated with hotspots of genomic instability. The fine mechanisms by which alternative DNA structures induce phenomena such as repeat expansions, chromosomal fragility, or gross chromosomal rearrangements are under intensive studies. It is well established that DNA damage checkpoint responses play a crucial role in maintaining a stable genome. It is far less clear, however, whether and how the checkpoint machinery responds to alternative DNA structures. This review discusses the role of the interplay between DNA damage checkpoints and alternative DNA structures in genome maintenance. (C) 2009 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available