Journal
MOLECULAR CANCER THERAPEUTICS
Volume 13, Issue 12, Pages 2930-2940Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1535-7163.MCT-14-0324
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Funding
- Ministry of Knowledge Economy, Korea [10030051]
- Korea Science and Engineering Foundation [2013K1A1A2A02050188, 2013M3A9D3045879, 2010-0029220]
- AIST, Japan Special Budget
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Ashwagandha is an important herb used in the Indian system of traditional home medicine, Ayurveda. Alcoholic extract (i-Extract) from its leaves and its component, withanone, were previously shown to possess anticancer activity. In the present study, we developed a combination of withanone and withaferin A, major withanolides in the i-Extract, that retained the selective cancer cell killing activity and found that it also has significant antimigratory, -invasive, and -angiogenic activities, in both in vitro and in vivo assays. Using bioinformatics and biochemical approaches, we demonstrate that these phytochemicals caused downregulation of migration-promoting proteins hnRNP-K, VEGF, and metalloproteases and hence are candidate natural drugs for metastatic cancer therapy. (C)2014 AACR.
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