Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 58, Issue 6, Pages 564-569Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-015-4829-0
Keywords
Huntington's disease; berberine; autophagy; protein aggregation
Categories
Funding
- NIA NIH HHS [R01 AG019206] Funding Source: Medline
- NINDS NIH HHS [R01 NS036232, R01 NS041669] Funding Source: Medline
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Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR's effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer's disease (AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson's disease (PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.
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