Journal
MOLECULAR CANCER THERAPEUTICS
Volume 11, Issue 6, Pages 1311-1319Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1535-7163.MCT-11-0905
Keywords
-
Categories
Funding
- Women's Endowment
- Carl and Roberta Deutsch Family Foundation
- Joan English Fund for Women's Cancer Research
- Kelly Day
- Foundation Leducq
- VA Merit I Award
- Ovarian Cancer Coalition
- Helen Beller Foundation
- Wendy Stark Foundation
- Sue and Mel Geleibter Family Foundation
- US Public Health Service [HL-30568, HL-082823]
- University of California, Los Angeles
Ask authors/readers for more resources
Recent studies suggest that high-density lipoprotein (HDL) levels are inversely related to colon cancer risk. HDL mimetics constructed from a number of peptides and proteins with varying structures possess anti-inflammatory and antioxidant properties reminiscent of HDL. In this article, we examined whether HDL mimetics, L-4F (an apolipoprotein A-I mimetic peptide) and G* (an apolipoprotein J mimetic peptide) affect tumor growth and development in mouse models of colon cancer. HDL mimetics reduced viability and proliferation of CT26 cells, a mouse colon adenocarcinoma cell line, and decreased CT26 cell-mediated tumor burden in BALB/c mice when administered subcutaneously or orally. Plasma levels of lysophosphatidic acid (LPA), a serum biomarker for colon cancer, were significantly reduced in mice that received HDL mimetics, suggesting that binding and removal of proinflammatory lipids is a potential mechanism for the inhibition of tumor development by HDL mimetics. Furthermore, L-4F significantly reduced size and number of polyps in APC(min/+) mice, a mouse model for human familial adenomatous polyposis, suggesting that HDL mimetics are effective in inhibiting the development of both induced and spontaneous cancers of the colon. Our results, for the first time, identify HDL mimetics as a novel therapeutic strategy for the treatment of colon cancer. Mol Cancer Ther; 11(6); 1311-9. (C)2012 AACR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available