Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 58, Issue 7, Pages 658-665Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-015-4866-8
Keywords
biofabrication; automation; metabolic engineering; biosystems design; DNA assembly; DNA sequencing; metabolite analysis
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Funding
- National Institutes of Health [GM077596]
- National Academies Keck Futures Initiative on Synthetic Biology
- Defense Advanced Research Program Agency
- Roy J. Carver Charitable Trust
- Institute for Genomic Biology at the University of Illinois at Urbana-Champaign
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Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological foundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries.
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