Journal
MOLECULAR CANCER RESEARCH
Volume 7, Issue 12, Pages 1902-1919Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1541-7786.MCR-09-0317
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Funding
- European Social Fund and National Rcsources-(EPEAFK-II)
- PYTHAGORAS II [7953]
- European Commission
- SARG-NKUA [70/3/1703, 70/4/9913, 70/4/4281]
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p57(KIP2) is an imprinted gene located at the chromosomal locus 11p15.5. It is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes additionally p21(CIP1/WAF1) and p27(KIP1). It is the least studied CIP/KIP member and has a unique role in embryogenesis. p57(KIP2) regulates the cell cycle, although novel functions have been attributed to this protein including cytoskeletal organization. Molecular analysis of animal models and patients with Beckwith-Wiedemann Syndrome have shown its nodal implication in the pathogenesis of this syndrome. p57(KIP2) is frequently down-regulated in many common human malignancies through several mechanisms, denoting its anti-oncogenic function. This review is a thorough analysis of data available on p57(KIP2), in relation to p21(CIP1/WAF1) and p27(KIP1), on gene and protein structure, its transcriptional and translational regulation, and its role in human physiology and pathology, focusing on cancer development. (Mol Cancer Res 2009;7(12):1902-19)
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