Journal
MOLECULAR CANCER
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12943-018-0852-7
Keywords
Long non-coding RNAs; Prostate cancer (PC); Biomarker; Tumorigenesis
Categories
Funding
- National Natural Science Foundation of China [81700522, 81470003]
- Provincial Natural Science Research Project of Colleges and Universities of Anhui Province, from the Education Department of Anhui, China [KJ2016A348]
- fund of Anhui medical university doctoral start research, from Anhui Medical University, China [0601067101]
- Anhui Medical University early contact research of clinical medicine, from Anhui Medical University, China [2015-ZQKY-47]
- Guangdong Province Science and Technology Project, from Guangdong Province Science and Technology Department, China [2013B021800164]
- Sichuan Medical Law Research Center, from Sichuan Province Science and Technology Department, China [YF16-Y22]
- Humanities and Social Science Research Project of Colleges and Universities of Anhui Province, from Anhui Province Science and Technology Department, China [SK2016A0482]
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Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Recent advances in the nonprotein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack coding protein function, termed non-coding RNA (ncRNA). It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in diverse diseases are not yet fully understood. Thus, it is anticipated that more efforts should be made to clarify the lncRNA world. Moreover, accumulating evidence has demonstrated that many lncRNAs are dysregulated in prostate cancer (PC) and closely related to tumorigenesis, metastasis, and prognosis or diagnosis. In this review, we will briefly outline the regulation and functional role of lncRNAs in PC. Finally, we discussed the potential of lncRNAs as prospective novel targets in PC treatment and biomarkers for PC diagnosis.
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