Journal
MOLECULAR CANCER
Volume 9, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1476-4598-9-252
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Funding
- China National Natural Scientific Fund [30971136, 30872657]
- Tianjin Science and Technology Committee [09JCZDJC17600]
- Program for New Century Excellent Talents in University [NCET-07-0615]
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beta-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant beta-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to beta-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of beta-catenin targeted therapeutics for cancer treatment.
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