Journal
MOLECULAR BIOTECHNOLOGY
Volume 44, Issue 2, Pages 152-167Publisher
SPRINGERNATURE
DOI: 10.1007/s12033-009-9220-6
Keywords
ABCB1; ABCC1; ABCC2; ABCG2; OATP1B3; OATP1B1; Pharmacogenetics; Membrane transporters
Funding
- National Cancer Institute, National Institutes of Health [N01-CO-12400, HHSN261200800001E]
- NIH, National Cancer Institute, Center for Cancer Research
Ask authors/readers for more resources
This review provides an overview of the pharmacogenetics of membrane transporters including selected ABC transporters (ABCB1, ABCC1, ABCC2, and ABCG2) and OATPs (OATP1B1 and OATP1B3). Membrane transporters are heavily involved in drug clearance and alters drug disposition by actively transporting substrate drugs between organs and tissues. As such, polymorphisms in the genes encoding these proteins may have significant effects on the absorption, distribution, metabolism and excretion of compounds, and may alter pharmacodynamics of many agents. This review discusses the techniques used to identify substrates and inhibitors of these proteins and subsequently to assess the effect of genetic mutation on transport, both in vitro and in vivo. A comprehensive list of substrates for the major drug transporters is included. Finally, studies linking transporter genotype with clinical outcomes are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available