Journal
SCIENCE CHINA-CHEMISTRY
Volume 59, Issue 1, Pages 40-52Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-015-5519-2
Keywords
photosensitizer; singlet oxygen; photodynamic therapy; cyclometalated; transition-metal complexes
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Funding
- National Natural Science Foundation of China [91227202, 21222403]
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The aim of this review article is to introduce recent studies on an emergent class of singlet oxygen photosensitizers of potential applications to the photodynamic therapy, with a primary focus on the cyclometalated transition-metal complexes. Singlet oxygen photosensitization performances of various cyclometalated Ir and Pt scaffolds are reviewed, and the general photo-physical properties of relevant systems and the mechanisms of singlet oxygen production via photo-sensitization are also briefly discussed. Thus far, investigations of singlet oxygen sensitization by such Ir and Pt complexes are mainly carried out in organic solvents and under non-physiological conditions, while some research efforts have been made at examining the feasibility of applying pertinent cyclometalated complexes to photodynamic therapy.
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