4.1 Review

Sirtuin 6: a review of biological effects and potential therapeutic properties

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Carlos Sebastian et al.

Review Biochemistry & Molecular Biology

Sirtuin Modulators: Mechanisms and Potential Clinical Implications

S. Sanchez-Fidalgo et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Review Cell Biology

Regulation and protection of mitochondrial physiology by sirtuins

Claudia V. Pereira et al.

MITOCHONDRION (2012)

Article Cell Biology

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

Gaoxiang Jia et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

John E. Dominy et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nagalingam R. Sundaresan et al.

NATURE MEDICINE (2012)

Article Chemistry, Medicinal

Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors

Piia Kokkonen et al.

ACS MEDICINAL CHEMISTRY LETTERS (2012)

Article Cell Biology

Structure-based development of novel sirtuin inhibitors

Christine Schlicker et al.

AGING-US (2011)

Article Biochemistry & Molecular Biology

After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders

Kilian Huber et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Review Biochemistry & Molecular Biology

SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

Yu Wang et al.

FEBS LETTERS (2011)

Article Biochemistry & Molecular Biology

Structure and Biochemical Functions of SIRT6

Patricia W. Pan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemical Research Methods

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

Chao Peng et al.

MOLECULAR & CELLULAR PROTEOMICS (2011)

Article Multidisciplinary Sciences

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Zhiyong Mao et al.

SCIENCE (2011)

Article Multidisciplinary Sciences

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

Jintang Du et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

Chromatin regulation and genome maintenance by mammalian SIRT6

Ruth I. Tennen et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

Article Genetics & Heredity

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks

Tiara L. A. Kawahara et al.

PLOS GENETICS (2011)

Review Cell Biology

Aging and disease: connections to sirtuins

Gizem Donmez et al.

AGING CELL (2010)

Review Biochemistry & Molecular Biology

NAD: A master regulator of transcription

Sanchari Ghosh et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2010)

Review Biochemistry & Molecular Biology

Sirtuin chemical mechanisms

Anthony A. Sauve

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)

Article Biochemistry & Molecular Biology

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Lei Zhong et al.

Article Cell Biology

SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology

Kai Harting et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

Cuiying Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Cell Biology

Genomic instability - an evolving hallmark of cancer

Simona Negrini et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

DNA resection in eukaryotes: deciding how to fix the break

Pablo Huertas

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

G. L. Semenza

ONCOGENE (2010)

Article Multidisciplinary Sciences

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

Bjoern Schwer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

SIRT6 A master epigenetic gatekeeper of glucose metabolism

Lei Zhong et al.

TRANSCRIPTION-AUSTIN (2010)

Review Cell Biology

The ageing epigenome: Damaged beyond repair?

David A. Sinclair et al.

AGEING RESEARCH REVIEWS (2009)

Article Cell Biology

Sirtuins at the breaking point: SIRT6 in DNA repair

David B. Lombard

AGING-US (2009)

Review Cell Biology

Chromatin modifications: The driving force of senescence and aging?

Teresa DiMauro et al.

AGING-US (2009)

Article Biochemistry & Molecular Biology

Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse

Ulrich Mahlknecht et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Editorial Material Biochemistry & Molecular Biology

When Sirtuins and NF-κB Collide

Gioacchino Natoli

Article Biochemistry & Molecular Biology

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

Lei Jin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Identification of the ADP-Ribosylation Sites in the PARP-1 Automodification Domain: Analysis and Implications

Zhihua Tao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Biochemistry & Molecular Biology

CUP Links DNA Double-Strand Break Sensing to Resection

Zhongsheng You et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

CBP/p300-mediated acetylation of histone H3 on lysine 56

Chandrima Das et al.

NATURE (2009)

Review Multidisciplinary Sciences

Recent progress in the biology and physiology of sirtuins

Toren Finkel et al.

NATURE (2009)

Article Genetics & Heredity

Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

Lucinda K. Southworth et al.

PLOS GENETICS (2009)

Review Biochemistry & Molecular Biology

Therapeutic role of sirtuins in neurodegenerative disease

Tiago Fleming Outeiro et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)

Review Oncology

Tumor cell metabolism: Cancer's Achilles' heel

Guido Kroemer et al.

CANCER CELL (2008)

Article Cell Biology

Reversal of aging by NFκB blockade

Adam S. Adler et al.

CELL CYCLE (2008)

Review Biochemistry & Molecular Biology

The Sirtuin family: therapeutic targets to treat diseases of aging

Jill C. Milne et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2008)

Article Pharmacology & Pharmacy

Inhibitors of NAD+ Dependent Histone Deacetylases (Sirtuins)

Manfred Jung et al.

CURRENT PHARMACEUTICAL DESIGN (2008)

Article Biochemistry & Molecular Biology

Regulation of SIRT6 protein levels by nutrient availability

Yariv Kanfi et al.

FEBS LETTERS (2008)

Article Medicine, General & Internal

SIRT6 in DNA repair, metabolism and ageing

D. B. Lombard et al.

JOURNAL OF INTERNAL MEDICINE (2008)

Article Biochemistry & Molecular Biology

Substrates and regulation mechanisms for the human mitochondrial Sirtuins Sirt3 and Sirt5

Christine Schlicker et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Eriko Michishita et al.

NATURE (2008)

Review Biotechnology & Applied Microbiology

Sirtuins - novel therapeutic targets to treat age-associated diseases

Siva Lavu et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Review Cell Biology

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

Xiang-Jiao Yang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Cell Biology

Motif module map reveals enforcement of aging by continual NF-κB activity

Adam S. Adler et al.

GENES & DEVELOPMENT (2007)

Review Biochemistry & Molecular Biology

Changes in DNA repair during aging

Vera Gorbunova et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Multidisciplinary Sciences

Human CtIP promotes DNA end resection

Alessandro A. Sartori et al.

NATURE (2007)

Article Genetics & Heredity

From broken to old: DNA damage, IGF1 endocrine suppression and aging

Raymond J. Monnat

DNA REPAIR (2007)

Article Biochemistry & Molecular Biology

GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis

Wenbin Ma et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2007)

Review Medicine, General & Internal

Aging, adiposity, and calorie restriction

Luigi Fontana et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)

Article Biochemistry & Molecular Biology

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

Anja Schuetz et al.

STRUCTURE (2007)

Letter Medicine, Research & Experimental

Is SIRT6 a new biomarker for oxidative stress and longevity assurance gene?

Chang-Su Lim

MEDICAL HYPOTHESES (2007)

Review Genetics & Heredity

The mechanics of base excision repair, and its relationship to aging and disease

David M. Wilson et al.

DNA REPAIR (2007)

Review Cell Biology

Nucleotide excision repair disorders and the balance between cancer and aging

Jaan-Olle Andressoo et al.

CELL CYCLE (2006)

Article Multidisciplinary Sciences

Inflammation and metabolic disorders

Goekhan S. Hotamisligil

NATURE (2006)

Article Biochemistry & Molecular Biology

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

R Mostoslavsky et al.

Review Microbiology

Nuclear ADP-ribosylation reactions in mammalian cells: Where are we today and where are we going?

Paul O. Hassa et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2006)

Review Biochemistry & Molecular Biology

The Sir2 family of protein deacetylases

JM Denu

CURRENT OPINION IN CHEMICAL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

G Liszt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Immunology

Insights into thymic aging and regeneration

DD Taub et al.

IMMUNOLOGICAL REVIEWS (2005)

Review Immunology

Inflammation-associated cancer:: NF-κB is the lynchpin

QT Li et al.

TRENDS IN IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Effects of fenugreek seed extract in obese mice fed a high-fat diet

T Handa et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2005)

Review Biochemistry & Molecular Biology

DNA repair, genome stability, and aging

DB Lombard et al.

Article Biochemistry & Molecular Biology

Coenzyme specificity of Sir2 protein deacetylases - Implications for physiological regulation

MT Schmidt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Oncology

Histone deacetylase inhibitors - a new tool to treat cancer

R Somech et al.

CANCER TREATMENT REVIEWS (2004)

Article Biochemistry & Molecular Biology

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

A Vaquero et al.

MOLECULAR CELL (2004)

Review Biotechnology & Applied Microbiology

Sirtuins: Sir2-related NAD-dependent protein deacetylases

BJ North et al.

GENOME BIOLOGY (2004)

Article Biochemistry & Molecular Biology

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

SF El-Khamisy et al.

NUCLEIC ACIDS RESEARCH (2003)

Article Multidisciplinary Sciences

POT1 as a terminal transducer of TRF1 telomere length control

D Loayza et al.

NATURE (2003)

Article Respiratory System

Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

A Di Stefano et al.

EUROPEAN RESPIRATORY JOURNAL (2002)

Article Critical Care Medicine

Airway inflammation in severe chronic obstructive pulmonary disease -: Relationship with lung function and radiologic emphysema

G Turato et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)

Article Biochemistry & Molecular Biology

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

RA Frye

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Article Critical Care Medicine

The role of nuclear factor-κ B in pulmonary diseases

JW Christman et al.

CHEST (2000)

Article Biochemistry & Molecular Biology

Repair of endogenous DNA damage

T Lindahl et al.

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (2000)