4.1 Article

Human cathelicidin peptide LL37 binds telomeric G-quadruplex

Journal

MOLECULAR BIOSYSTEMS
Volume 9, Issue 7, Pages 1833-1836

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3mb70030e

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Funding

  1. DBT-RGYI research Grant [BT/PR6627/GBD/27/440/2012]
  2. DST Fast track Govt. of India [SR/FT/LS-100/2012]
  3. CSIR, Govt. of India

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Stabilization of G-quadruplex inhibits the activity of the enzyme telomerase in cancer cells. We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures.

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