Journal
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume 16, Issue 2, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1088/1468-6996/16/2/023501
Keywords
magnetic iron oxide nanoparticles; surface functional strategy; biomedical application
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Funding
- NSFC [51201115, 51171132, 11375134]
- China's Postdoctoral Science Foundation [2014M550406]
- Hong Kong Scholars Program
- Hubei Provincial Natural Science Foundation [2014CFB261]
- Fundamental Research Funds for the Central Universities
- Fundamental Research Funds for the Wuhan University
- National Research Foundation of Korea [22A20130000014] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.
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