Journal
MOLECULAR BIOSYSTEMS
Volume 8, Issue 10, Pages 2527-2530Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2mb25016k
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- Canadian Institutes of Health Research [FRN 102725]
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The majority of vertebrate mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain elements at the 5' end of the ORF that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that these elements promote efficient export and proper cytoplasmic localization only when they are found at the 5' end of the transcript.
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