Journal
MOLECULAR BIOSYSTEMS
Volume 7, Issue 1, Pages 48-51Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0mb00015a
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Funding
- University of South Carolina
- NIH [GM079357]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R25GM076277, R25GM066526, R01GM079357] Funding Source: NIH RePORTER
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The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1 inhibitor with enhanced selectivity.
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