Journal
MOLECULAR BIOSYSTEMS
Volume 6, Issue 1, Pages 55-64Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b916371a
Keywords
-
Categories
Funding
- Systems Biology DTC
Ask authors/readers for more resources
Here we review the methods for the prediction of protein interactions and the ideas in protein evolution that relate to them. The evolutionary assumptions implicit in many of the protein interaction prediction methods are elucidated. We draw attention to the caution needed in deploying certain evolutionary assumptions, in particular cross-organism transfer of interactions by sequence homology, and discuss the known issues in deriving interaction predictions from evidence of co-evolution. We also conject that there is evolutionary knowledge yet to be exploited in the prediction of interactions, in particular the heterogeneity of interactions, the increasing availability of interaction data from multiple species, and the models of protein interaction network growth.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available