Journal
MOLECULAR BIOSYSTEMS
Volume 6, Issue 8, Pages 1366-1375Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c003468a
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Funding
- NIH [P01-DK58398]
- National Heart Lung and Blood Institute [N01-HV-28185]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK058398] Funding Source: NIH RePORTER
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The orexins are neurohormones that, in concert with their cognate receptors, regulate a number of important physiological processes, including feeding, sleep, reward seeking and energy homeostasis. The orexin receptors have recently emerged as important drug targets. This review provides an overview of recent development in deciphering the biology of orexin signaling as well as efforts to manipulate orexin signaling pharmacologically.
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