Journal
MOLECULAR BIOSYSTEMS
Volume 5, Issue 11, Pages 1306-1310Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b900880b
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Funding
- Grant-in-Aid for Exploratory Research [18650124]
- Grant-in-Aid for Scientific Research [19300172]
- Japan Society for the Promotion of Science (JSPS)
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Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.
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