Journal
MOLECULAR BIOSYSTEMS
Volume 5, Issue 9, Pages 1051-1057Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b905821b
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Funding
- Spanish Ministerio de Ciencia y Educacion [BIO2008-02329]
- Instituto de Salud Carlos III
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The availability of interaction data between small molecule drugs and protein targets has increased substantially in recent years. Using seven different databases, we were able to assemble a total of 4767 unique interactions between 802 drugs and 480 targets, which means that on average every drug is currently acknowledged to interact with 6 targets. The application of network theory to the analysis of these data reveals an unexpectedly complex picture of drug-target interactions. The results confirm that the topology of drug-target networks depends implicitly on data completeness, drug properties, and target families. The implications for drug discovery are discussed.
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